In the fight against this disease, early diagnosis is fundamental; therefore, the World Health Organization continues to urge the development of new rapid diagnostic tests that can be used in endemic areas. Unlike the other tests currently available, TMek does not exploit a chemical mechanism (identification of a DNA molecule or an antigen linked to the proliferation of plasmodium) but a physical one, linked to the variation of the magnetic properties of infected red blood cells that, due to the presence of hemozoin, can be separated in an appropriate magnetic field. TMek, therefore, uses a microchip in which magnetic micro-concentrators are made with electrodes on top, thus allowing the capture and quantification of infected blood cells through an electrical measurement. TMek was first tested in Cameroon in April 2019 with decidedly promising results.
The main innovative features of TMek are
– Ability to quantify the concentration of parasites, useful to identify the stage of the disease and follow the patient in the treatment phase. The rapid diagnostic tests currently used only give an indication of the presence/absence of parasites.
–High sensitivity (up to 10 parasites per microliter of blood) in a test that takes only 10 minutes. Current rapid diagnostic tests have a detection limit of 200 parasites per microliter and a duration of 15-20 minutes.
– Absence of false negatives (the risk of a malaria patient being judged healthy is very low).
– Ability to distinguish the presence of parasites in the asexual phase (acute phase of the disease) and the sexual phase (after the disease, typically in healthy carriers). This constitutes a unique feature for rapid malaria testing and opens the door to the use of TMek for healthy carrier screening and subsequent treatment to block transmission of the infection.
TMek is a project with a social purpose and is protected by "social" patents, filed to ensure ethical use of any proceeds from the exploitation of intellectual property. The inventors have waived their rights in favor of funding research projects with a social purpose.
Donate to ensure the ethical development of TMek and create a unique diagnostic tool in the fight against malaria.
The fundraising campaign in memoriam of Marco Seclì is aimed at supporting students of Mathematical Engineering of our University living outside Milan and commuting everyday in the city to study.
Dynamis PRC is the Formula Student team of Politecnico di Milano. Consisting of more than one hundred engineering students each year, the team designs and builds a formula-style racing prototype. It ranks as the first Italian team and fourth in the world in the combustion category. In 2020 the team switched to a fully electric prototype, obtaining a third place in Formula Student Online, the replacement event organized to make up for the lack of physical races.
The team of Politecnico di Milano participates in the first car race for autonomous vehicles
39 universities from 11 different countries will partecipate in the Indy Autonomous Challenge. 1.5 million dollars to be won by programming the sportscar Dallara IL_15.
The scholarship fundraising 10 students |10 stories organised by the School of Management of Politecnico di Milano has the goal of helping 10 students in need to realize their dream: studying managing engineering at Politecnico di Milano.
We call to support all Alumni of Management Engineering and all friends of the Department who believe in the ability of the School of Management to have a positive impact on the world of the future.